129Xe MRI Cardiopulmonary

Inclusion criteria

• for Healthy Volunteers:
• Inclusion Criteria: Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial)
• Outpatients of either gender, age \> 18
• Willing and able to give informed consent and adhere to visit/protocol (Consent must be given before any study procedures are performed.)
• Subject has no diagnosed pulmonary conditions
• Subject has not smoked in the previous 5 years
• Smoking history, if any, is less than or equal to 5 pack-years
• No history of using other inhaled products more than 1/week for \> 1 year
• Inclusion Criteria for Transfusion and Phlebotomy Patients:
• In-patient or outpatients of either sex, age \> 18
• Willing and able to give informed consent and adhere to visit/protocol
• And one of the following:
• Patients who are scheduled to receive a red cell transfusion for anemia.
• Patients who are scheduled to undergo therapeutic phlebotomy to treat erythrocytosis or polycythemia
• Healthy volunteers undergoing voluntary whole blood donation (healthy volunteer inclusion criteria noted above)
• Inclusion Criteria for Oxygen Administration Patients:
• In-patient or outpatients of either sex, age \> 18
• Willing and able to give informed consent and adhere to visit/protocol
• And one of the following categories (ILD, Dyspnea, CTEPH, or Healthy):
• Interstitial Lung Disease or Dyspnea
• Physician diagnosis of Interstitial Lung Disease by a pulmonologist using established criteria or physician referral of patient with dyspnea
• Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
• Patients with a diagnosis of CTEPH, defined as mean PA pressure \>20 mmHg with a pulmonary vascular resistance \>2 WU and pulmonary capillary wedge pressure ≤15 mmHg at right heart catheterization with evidence of chronic thromboembolic disease on clinical imaging after 3 months of anticoagulation
• Scheduled for pulmonary thromboendoarterectomy (PTE) surgery and willing to re-turn 3-6 months after for optional follow-up scans
• Healthy Volunteer (criteria noted above)
• Inclusion Criteria for Acute or Chronic Pulmonary Embolism Patients:
• In-patient or outpatients of either sex, age \> 18
• Willing and able to give informed consent and adhere to visit/protocol
• And one of the following categories (Acute or Chronic)
• Acute Pulmonary Embolism
• Patients presenting with acute PE 24-48hrs post-admission
• Willing to return after 3-6 months of anti-coagulation therapy
• Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
• Patients with a diagnosis of CTEPH, defined as mean PA pressure \>20 mmHg with a pulmonary vascular resistance \>2 WU and pulmonary capillary wedge pressure ≤15 mmHg at right heart catheterization with evidence of chronic thromboembolic disease on clinical imaging after 3 months of anticoagulation
• Scheduled for pulmonary thromboendoarterectomy (PTE) surgery and willing to re-turn 3-6 months after for optional follow-up scans

Exclusion criteria

• for All subjects:
• Subjects presenting with any of the following will not be included in the trial:
• MRI is contraindicated based on responses to MRI screening questionnaire
• Subject is pregnant or lactating
• Resting O2 saturation \<90% with maximum supplemental O2 delivered by nasal canula
• Respiratory illness of a bacterial or viral etiology within 30 days of MRI
• Subject has history of any known ventricular cardiac arrhythmia
• Subject has history of cardiac arrest within the last year
• Subject does not fit into 129Xe vest coil used for MRI
• Subject cannot hold his/her breath for 10 seconds
• Subject deemed unlikely to be able to comply with instructions during imaging
• Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements