The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
Recruiting · NCT06058585 · Interventional (participants receive a specific treatment) · Lead sponsor: The George Institute
View the official record on ClinicalTrials.gov →Interventions studied
FinerenonePlacebo Finerenone
What this trial is about
CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD). CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure. CAPTIVATE provides a research platform that allows many treatment-related questions to be answered within a common trial set-up.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 18 years
- Known chronic kidney disease from any cause (eGFR ≥25 mL/min/1.73m2)
- Currently receiving standard of care treatment according to treating physician
- Eligible for randomisation in at least one recruiting domain-specific appendix
- Participant and treating physician are willing and able to perform trial procedures
Exclusion criteria
- Planned to commence kidney replacement therapy or kidney transplant surgery in next 6 months
- Life expectancy less than 6 months
Where it is running
43 locations listed.
- Health New Zealand, Te Whatu Ora Waitemata, North Shore Hospital - Auckland, New Zealand
- Auckland City Hospital - Auckland, New Zealand
- Aotearoa Clinical Trials Trust, Middlemore Hospital - Auckland, New Zealand
- National Hospital of Sri Lanka - Colombo, Sri Lanka
- Max Superspeciality Hospital, Dehradun - Dehradun, India
- 201 Great King Street, Central Dunedin, Dunedin 9016, New Zealand - Dunedin, New Zealand
- Kandy National Hospital - Kandy, Sri Lanka
- Kurunegala Teaching Hospital - Kurunegala, Sri Lanka
- Sri Jayewardenepura General Hospital - Nugegoda, Sri Lanka
- Peradeniya Teaching Hospital - Peradeniya, Sri Lanka
- Colombo North Teaching Hospital - Ragama, Sri Lanka
- Private Bag 9742 Maunu Road, Horahora, Whangārei 0148, New Zealand - Whangarei, New Zealand
- Gitam Institute of Medical Sciences and Research - Visakhapatnam, Andhra Pradesh, India
- The Canberra Hospital - Garran, Australian Capital Territory, Australia
- Patna Medical College and Hospital - Patna, Bihar, India
- DKS Super Speciality Hospital, Raipur - Raipur, Chhattisgarh, India
- Mysore Medical College - Dehradun, Dehradun, India
- Hospital Clinico Universitario València (INCLIVA) - Valencia, Espana, Spain
- GCS Medical College, Hospital & Research Centre - Ahmedabad, Gujarat, India
- Health New Zealand, Te Whatu Ora Te Matau a Maui, Hawke's Bay Hospital - Hastings, Hawkes Bay, New Zealand
- Father Muller Medical College Hospital - Mangaluru, Karnataka, India
- Dr Moopen's Medical College - Meppādi, Kerala, India
- CARE-CHL Hospital - Indore, Madhya Pradesh, India
- Nepean Blue Mountains Local Health District - Kingswood, New South Wales, Australia
- St George Hospital - Kogarah, New South Wales, Australia
- John Hunter Hospital - New Lambton Heights, New South Wales, Australia
- Westmead Hospital - Westmead, New South Wales, Australia
- National Nephrology Specialized Hospital - Colombo, Polonnaruwa, Sri Lanka
- Sunshine Coast Hospital and Health Service - Birtinya, Queensland, Australia
- Townsville University Hospital - Douglas, Queensland, Australia
- West Moreton Hospital & Health Service - Ipswich, Queensland, Australia
- Gold Coast Hospital and Health Service - Southport, Queensland, Australia
- Royal Adelaide - Adelaide, South Australia, Australia
- Lyell McEwin Hospital - Elizabeth Vale, South Australia, Australia
- Medway Hospital - Chennai, Tamil Nadu, India
- Yashoda Hospital Hitec City - Hyderabad, Telangana, India
- Apollo Hospitals - Hyderabad, Telangana, India
- Charak Hospital and Research Centre - Lucknow, Uttar Pradesh, India
- Shri Guru Ram Rai Medical College and Shri Mahant Indiresh Hospital - Dehradun, Uttarakhand, India
- Austin Health - Heidelberg, Victoria, Australia
- Fortis Hospital - Kolkata, West Bengal, India
- North Bengal Medical College & Hospital - Siliguri, West Bengal, India
- South Metropolitan Health Service, Fiona Stanley Hospital - Murdoch, Western Australia, Australia