Metabolic Mechanisms of the Electrophysiological Biomarkers for Response to Methylphenidate Treatment in Children With ADHD
Recruiting · NCT06073470 · Observational (researchers observe without assigning treatment) · Lead sponsor: National Taiwan University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
To explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects of methylphenidate in children with ADHD.
Who can take part
Age range
6 Years to 18 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Patients, aged 6 to 18 years, meet the DSM-5 diagnostic criteria for ADHD.
- At baseline, patients have a Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) score greater than 4.
- Patients have a Full IQ (FIQ) score greater than 80.
Exclusion criteria
- Patients have a major psychiatric disorder, such as autism spectrum disorder, schizophrenia, affective disorders, or substance use disorders.
- Patients have a major disorder of central nervous system, such as epilepsy.
- Patients have a major systemic disease, such as diabetes mellitus or cardiovascular diseases.
- Patients have ever received any medication to treat the clinical symptoms of ADHD.
- Neurotypical participants:
- Inclusion Criteria
- aged 6 to 18 years
- All of the neurotypical participants have no psychiatric disorder in lifetime according to the diagnostic criteria of DSM-5.
- Exclusion Criteria
- participants have any disorder of central nervous system or major systemic disease
- participants have ever taken any psychotropic drug, or who have FIQ scores less than 80, will be excluded from the present study.
Where it is running
1 location listed.
- National Taiwan University Hospital - Taipei, Taiwan