Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment
Recruiting · NCT06090682 · Observational (researchers observe without assigning treatment) · Lead sponsor: Tianjin Huanhu Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)
What this trial is about
This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.
Who can take part
Age range
Up to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- \. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.
Exclusion criteria
- Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.
Where it is running
1 location listed.
- Tianjin Huanhu Hospital - Tianjin, Tianjin Municipality, China