Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension
Recruiting · NCT06098300 · Observational (researchers observe without assigning treatment) · Lead sponsor: Medical University of Vienna
View the official record on ClinicalTrials.gov →What this trial is about
To evaluate whether in patients with initially poorly-controlled arterial hypertension, structural and functional differences in the retina and choroid remain after achieving a well-controlled blood pressure.
Who can take part
Age range
18 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Men and Women aged ≥ 18 years
- Signed informed consent
- Apart from hypertensive retinopathy, normal ophthalmic findings
- Non-Smokers
- Patients with initially diagnosed or pre-existing mild to moderate primary arterial hypertension (systolic office blood pressure ≥ 140 mmHg and/or diastolic office blood pressure ≥ 90 mmHg)
- Planned initiation of antihypertensive medication or planned adaption of antihypertensive medication by the Department of Cardiology
- Subject agrees to perform regular blood pressure self-measurements and to document blood pressure values in a diary
Exclusion criteria
- Participation in a clinical trial in the three weeks preceding the study
- Blood donation in the three weeks preceding the study
- Symptoms of a clinically relevant illness in the three weeks preceding the study
- History of family history of epilepsy
- Secondary hypertension (e.g.: hyperaldosteronism, pheochromocytoma, renal artery stenosis, renal parenchymal diseases, Cushing-syndrome, Coarctatio aortae)
- History of hypertensive encephalopathy or intracerebral bleeding
- Diabetes mellitus Type 1 or Type 2
- Pregnant or breast-feeding women
- Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception
Where it is running
1 location listed.
- Medical University of Vienna - Vienna, Austria