Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
Recruiting · NCT06105164 · Interventional (participants receive a specific treatment) · Lead sponsor: Brigham and Women's Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Repetitive Transcranial Magnetic Stimulation (rTMS)Sham repetitive Transcranial Magnetic Stimulation (rTMS)
What this trial is about
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Healthy individuals aged 18 to 65
- BMI of 20-35.0 kg/m2
- Normal or corrected-to-normal vision
- Good general health
- Ability to understand and willingness to sign written informed consent document
Exclusion criteria
- Current and/or past medical conditions
- Current and/or past eating disorder
- On a restricted diet and/or taking weight loss medication(s)
- History of bariatric surgery
- Weight fluctuation \>3% in past 3 months
- Recent history of illicit recreational drug abuse
- Current nicotine use
- Intellectual disability
- Conditions that might result in increased risks of side effects or complications from TMS or MRI
Where it is running
2 locations listed across 1 US state.
- McLean Hospital - Belmont, Massachusetts, United States
- Brigham and Women's Hospital - Boston, Massachusetts, United States