Addition of Hypofractionated High Dose Radiation in Oligometastatic Disease

Inclusion criteria

• Written informed consent obtained from the subject prior to performing any protocol- related procedures, including screening procedures
• Histological or cytological diagnosis of NSCLC
• Stage IV disease with ≤5 metastases (not including primary tumour or mediastinal nodes, N1-N3)
• Patient deemed fit for first line chemoimmunotherapy, immunotherapy or chemotherapy
• Extra-thoracic metastases accessible for stereotactic body radiotherapy (SBRT)
• Thoracic tumour(s) accessible for SBRT or conventional radiotherapy
• Received no prior systemic treatment or radiation therapy for NSCLC (previous adjuvant systemic therapy is allowed)
• Age \> 18 years at time of study entry, no upper age limit
• WHO performance status 0-2
• Adequate normal organ and marrow function Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal subjects.
• Subject is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up

Exclusion criteria

• • Solitary brain lesion or contralateral lung lesion as the only distant metastasis
• Participation in another clinical study with an investigational product during the last 4 weeks
• Patients with EGFR+, ALK+, ROS1+ disease or any other genetic alteration that would result in a TKI based first line treatment (i.e. first line treatment not being chemoimmuno- or immunotherapy)
• Malignant pleural fluid, or ascites (malignant cells or clinical judgement) or excessive fluid hampering radiation according to protocol
• Leptomeningeal disease
• Pulmonary fibrosis making protocol stipulated treatment hazardous (low grade radiologic findings are allowed as assessed by the investigator)
• Not deemed fit for standard first line systemic therapy
• Second primary residual malignancy. Other malignancy diagnosed and treated \> 2 years ago without relapse and deemed to have a low likelihood of relapse is allowed. (Carcinoma in situ of the cervix or adequately treated basal cell carcinoma of the skin \< 2 years are allowed, as is other low-grade malignancy with low likelihood of becoming metastatic or impact on survival e.g. low-grade prostate cancer not in need of treatment)
• Female subjects who are pregnant or breastfeeding or male or female subjects of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose of systemic therapy
• Any condition that, in the opinion of the investigator, would interfere with evaluation of study treatment or interpretation of patient safety or study results