D-SOLVE Cohorts (Cohort a and B)
Recruiting · NCT06160635 · Observational (researchers observe without assigning treatment) · Lead sponsor: Hannover Medical School
View the official record on ClinicalTrials.gov →What this trial is about
Hepatitis D is by far the most severe form of chronic viral hepatitis, frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection Hepatitis D is caused by co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV). This multicenter cohort should enable a comprehensive and unbiased biomarker screening of well-defined HDV-infected patients, followed by mechanistic studies to determine the functional role of distinct molecules. Patient surveillance strategies and antiviral treatment approaches could be personalized which should reduce clinical and social disease burden, improve quality of life and save direct and indirect costs caused by HDV infection.
Who can take part
Inclusion criteria
- Anti-HDV positive
- ≥18 years old
- Sex: m/f/d
- Informed consent for prospective procedures
Exclusion criteria
- Anti-HDV negative
Where it is running
4 locations listed.
- Institutul de Boli Infectioase "Prof. Dr. Matei Bals" - Bucharest, Romania
- Hannover Medical School, Department of Gastroenterology, Hepatology, Infectious Disease and Endocrinology - Hanover, Germany
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (University of Milan) - Milan, Italy
- Karolinska University Hospital and Karolinska Institutet - Stockholm, Sweden