Greater-Bay-Area Healthy Aging Brain Study (GHABS)

Inclusion criteria

• This project intends to recruit men and women between the ages of 55 and 90. The inclusion criteria are as listed:
• Age 55-90 years old (including 55 and 90 years old). However, people with autosomal dominant and other familial Alzheimer disease (FAD) are not limited by age.
• The score of the Geriatric Depression Scale (GDS) is less than 6 points.
• There is a caregiver who can maintain at least 10 hours of contact per week and can accompany volunteers to the test site for testing.
• Visual and auditory acuity is sufficient for neuropsychological testing. (Including normal corrected vision and hearing)
• Be in good health and are expected to be free of disease interference during the study.
• Volunteers are not pregnant, lactating or have reproductive potential (that is, women must be two years after menopause or undergo sterilization surgery).
• Willingness and ability to participate in longitudinal imaging studies.
• A modified version of the Hachinski Ischemic scores less than or equal to 4.
• Have completed grade 6 education or have good work experience (sufficient to rule out mental retardation).
• Must be able to speak Mandarin fluently.
• Willing to undergo multiple 3T MRI scans and at least two PET scans.
• Agree to collect blood for genomic analysis (including GWAS sequencing and other analyses), AD risk and protective genes such as apolipoprotein E (APOE), klotho, etc., and biological sample storage.
• Agree to collect blood for biomarker detection.
• Agree to share genomic data and biomarker samples.

Exclusion criteria

• MRI brain scan screening reveals infection, infarction or other focal lesions or multiple lacunes or lacunes in key memory structures.
• Any volunteers who do not meet the MRI scan requirements, including having a cardiac pacemaker, eyes, skin or metal fragments or foreign bodies in the body.
• Severe depression, bipolar affective disorder described in DSM-IV in the past year.
• Psychotic features, agitation or behavioral problems that may lead to difficulty complying with the protocol content in the past 3 months.
• Currently using medication to treat obsessive-compulsive disorder or attention deficit disorder.
• History of schizophrenia (meeting DSM-IV criteria).
• History of alcohol or drug abuse or dependence within the past 2 years (metting DSM-IV criteria).
• Any major systemic disease or unstable physical condition that may make longitudinal research difficult.
• Clinically significant abnormalities of B12 or TFTs may interfere with the study, low B12 will be excluded.
• Currently using certain psychoactive medications (e.g., certain antidepressants, neuro-depressants, chronic anxiolytics, or sedative-hypnotics). Currently using warfarin or other anticoagulants such as dabigatran, rivaroxaban, and apixaban (except lumbar puncture).
• Use of prohibited drugs.
• Simultaneously participating in other clinical studies involving neuropsychiatry.