EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation
Recruiting · NCT06212791 · Observational (researchers observe without assigning treatment) · Lead sponsor: Virginia Commonwealth University
View the official record on ClinicalTrials.gov →Interventions studied
Ambulatory cardiac rhythm assessmentCardiopulmonary exercise test (CPET)Cardiovascular magnetic resonance (CMR)Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life QuestionnaireSelf- Report Evaluation-Duke Activity Status IndexTransthoracic echocardiogram
What this trial is about
Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Age ≥18 years
- Diagnosis of paroxysmal AF
- Left ventricular ejection fraction ≥50%
- Scheduled for catheter ablation
- Able to speak, hear, and read English
- Willing and able to provide informed consent
Exclusion criteria
- Persistent or permanent AF
- Prior ablation (catheter based or surgical) for AF
- Significant sinus node dysfunction
- Implanted pacemaker or defibrillator
- Contraindication to or inability to complete cardiovascular magnetic resonance study
- Contraindication to or inability to complete exercise testing
- Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
- Severe left ventricular hypertrophy
- Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:
- Hypertrophic cardiomyopathy
- Cardiac amyloidosis
- Constrictive pericarditis
- Pulmonary arterial hypertension
- Prior cardiac surgery
- Active pregnancy
Where it is running
1 location listed across 1 US state.
- Virginia Commonwealth University - Richmond, Virginia, United States