Studies of Phenotypic and Functional Characteristics of Circulating Neutrophil Subpopulations in Patients With Lung Cancer
Recruiting · NCT06244355 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Extra blood tubes
What this trial is about
The objective is to study the phenotypic, functional and metabolomic characteristics of neutrophils circulating subpopulations in lung cancer patients, and to compare them to a control group of healthy volunteers. A blood sample will be taken before the first treatment session for the lung cancer patient and a second blood sample will be taken during the first evaluation visit. The investigators hypothesize that there may be different circulating neutrophil subpopulations in patients with metastatic non-small cell lung cancer (NSCLC) involved in tumor progression and resistance to immunotherapy.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- common to lung cancer and COPD patients :
- Age ≥ 18 years,
- male or female,
- affiliated with a Health Insurance,
- Inclusion Criteria for lung cancer patients :
- \- Diagnosis of metastatic stage lung cancer with mutation status, naïve treatment
- Inclusion Criteria for COPD patients :
- \- Diagnosis of COPD post-smoking
Exclusion criteria
- Tuberculosis or other acute or chronic bacterial infections
- Chronic progressive viral infections (Hepatitis B and C, HIV)
- Previous or ongoing chemotherapy
- Impossibility of giving the subject informed information.
- Opposition to the research.
- Participation in another research study with an exclusion period still in progress at pre-inclusion (possible inclusion in an observational study)
- Vulnerable individual (pregnant, parturient or breastfeeding woman), persons under guardianship or curatorship, or deprived of liberty by a judicial or administrative decision)
- Patients benefiting from the AME
Where it is running
1 location listed.
- Assistance Publique - Hôpitaux de Paris (AP-HP) - Cochin Hospital - Pneumology unit - Paris, Île-de-France Region, France