Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM
Recruiting · NCT06256419 · Interventional (participants receive a specific treatment) · Lead sponsor: The Affiliated Hospital of Xuzhou Medical University
View the official record on ClinicalTrials.gov →Interventions studied
GLP-1 receptor agonistresponders group and nonresponders group
What this trial is about
This is a retrospective cohort study of patients with T2DM who were treated with exenatide twice daily as a part of their diabetes care for at least 12 months. The objective of this study is to investigate the influence of T2DM susceptibility gene polymorphisms (NOS1AP, KCNQ1, TCF7L2, WSF1, GLP-1R, etc.) on the efficacy of GLP-1 RA (exenatide, liraglutide, etc.), to identify the variables that can predict the efficacy of GLP-1 RA, and to evaluate the weight of these variables on the efficacy.
Who can take part
Age range
25 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- a diagnosis of T2DM
- a body mass index (BMI) of 20-35 kg/m2
- an HbA1c of 7.0%-12%, an age of 25-70 years
- required data available at baseline and 6 months after GLP-1RA therapy.
Exclusion criteria
- Patients with serious diseases such as acute myocardial infarction, cerebral vascular accident, trauma, kidney or liver diseases, severe gastrointestinal dysfunction, and history of pancreatitis
- patients receiving GLP-1 analogues, weight loss drugs, glucocorticoids, drugs affecting gastrointestinal peristalsis in the past 3 months
- those with missing data at the time points of baseline, 3 months, and 6 months after GLP-1 RA therapy.
Where it is running
1 location listed.
- China, Jiangsu, Department of Endocrinology - Xuzhou, China, China