Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

Recruiting · NCT06263426 · Interventional (participants receive a specific treatment) · Lead sponsor: Johns Hopkins University

Interventions studied

HIV D+/R+

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

Age range

18 Years and older

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Participant meets local criteria for kidney transplant.
Participant is able to understand and provide informed consent.
Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
Participant is ≥ 18 years old.
HIV-1 RNA \< 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \> 200 copies/mL.
Participant is not suffering from significant wasting (e.g. body mass index \<21) thought to be related to HIV disease.

Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of \> 1 month, or primary central nervous system (CNS) lymphoma.
Participant is pregnant or breastfeeding.
Past or current medical problems or findings from medical history, physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

18 locations listed across 11 US states.

University of Alabama at Birmingham - Birmingham, Alabama, United States
University of California, Davis - Sacramento, California, United States
University of California, San Diego - San Diego, California, United States
University of California, San Francisco - San Francisco, California, United States
Mayo Clinic Florida - Jacksonville, Florida, United States
Northwestern University - Chicago, Illinois, United States
Rush University Medical Center - Chicago, Illinois, United States
Ochsner Clinic Foundation - New Orleans, Louisiana, United States
Johns Hopkins University - Baltimore, Maryland, United States
Massachusetts General Hospital - Boston, Massachusetts, United States
Washington University St. Louis Barnes Jewish Hospital - St Louis, Missouri, United States
New York University - New York, New York, United States
Icahn School of Medicine at Mt. Sinai - New York, New York, United States
Columbia University - New York, New York, United States
Weill Cornell Medical Center - New York, New York, United States
University of Pennsylvania - Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center - Pittsburgh, Pennsylvania, United States
Houston Methodist Research Institute - Houston, Texas, United States