Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland
Recruiting · NCT06264427 · Interventional (participants receive a specific treatment) · Lead sponsor: Steno Diabetes Center Greenland
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this clinical trial is to perform a detailed description of the feno- and genotype of people living with type 2 diabetes and severe obesity who are linked to care at Steno Diabetes Center Greenland. The main questions it aims to answer are: * Are monogenetic diabetes variants associated with the same risk of developing late diabetic complications as other types of diabetes? * Can genotyping and thereby personalized medicine be implemented in Greenland, and can personalized medicine lead to improved treatment? * What is the prevalence of sleep apnea among high-risk individuals in Greenland? * Is it possible to develop and implement a simple algorithm for the identification of sleep apnea in Greenland that can ensure treatment of severe sleep apnea? Participants will: * Answer WHO-5 and FOSQ-10 questionnaires regarding quality of life and functional outcomes of sleepiness * Perform VAGUS examinations for Cardiovasculare Autonomic Neuropathy * Clinical examination of height, weight, circumference of hip, waist and neck, Friedman tonsil and tongue score, nasal air flow, nasal septal deviation * Blood samples for full genome sequencing
Who can take part
Inclusion criteria
- Type 2 diabetes and/or morbid obesity (BMI \>40)
- Over 18 years old
Exclusion criteria
- Does not speak either English, Danish or Greenlandic
Where it is running
1 location listed.
- Steno Diabetes Center Greenland, Queen Ingrids Hospital - Nuuk, Sermersooq, Greenland