A Study on the Correlation Between Endometriosis and Intra-tissue Microbiota
Recruiting · NCT06266897 · Observational (researchers observe without assigning treatment) · Lead sponsor: Zhujiang Hospital
View the official record on ClinicalTrials.gov →What this trial is about
Endometriosis (EM) is a common gynecological condition, but the pathogenesis of it has not yet been clarified. Here, the investigators wanted to investigate the correlation between endometriosis and the intra-tissue microbiota. The investigators planed to collect serum, vaginal swabs, cervical mucus, feces, peritoneal fluid, and endometrial tissue for sequencing and experiments.
Who can take part
Age range
18 Years to 52 Years
Sex
Female
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Women aged 18-52 years old.
- Regular menstruation with a cycle of 28-35 days.
- No sexual intercourse 1 week before the operation.
- No systemic or local use of antibiotics and probiotics for 6 months prior to surgery.
- No history of acute or chronic pelvic inflammatory disease.
- Subjects fully understand the significance of the study and sign the informed consent form.
Exclusion criteria
- In pregnancy.
- Intraoperative conditions or pathological examination suggest a malignant or junctional disease.
- Severe anatomical abnormalities of the pelvis.
- Pelvic contamination with large amounts of blood during laparoscopic operation.
- History of gene therapy, blood transfusion, stem cell therapy, or bone marrow transplantation
- Psychiatric, personality disorders, or abuse of psychoactive substances.
- Immunodeficiencies, allergies, or autoimmune diseases.
- Contraindications to endotracheal intubation anesthesia.
- Absolute or relative contraindications to laparoscopic or hysteroscopic surgery.
Where it is running
1 location listed.
- Zhujiang Hospital - Guangzhou, Guangdong, China