Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Recruiting · NCT06272461 · Interventional (participants receive a specific treatment) · Lead sponsor: University Tunis El Manar
View the official record on ClinicalTrials.gov →Interventions studied
Ketamine Injectable SolutionLidocaine IV
What this trial is about
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
Who can take part
Age range
18 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients aged 18 or older.
- American society of anesthesiologists' (ASA) physical status of I-III.
- Elective open colorectal surgery.
- NON INCLUSION CRITERIA:
- Patients with contraindications to lidocaine or ketamine.
- Corticosteroid therapy within the last 6 months.
- History of immunosuppressive therapy.
- History of surgery in the last 3 months.
- Personal medical history of inflammatory bowel disease.
- Personal medical history of cardiac arrythmias or conduction disorders.
- Alcohol or drug abuse.
- Chronic use of opioids or benzodiazepines.
Exclusion criteria
- Severe intraoperative complications.
- Duration of surgery longer than 5 hours.
Where it is running
1 location listed.
- Tunisia - Nabeul, Tunisia