Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
Recruiting · NCT06278285 · Interventional (participants receive a specific treatment) · Lead sponsor: Centre Hospitalier Universitaire de Nice
View the official record on ClinicalTrials.gov →Interventions studied
Blood GLP1Blood No treated GLP1
What this trial is about
Normalizing weight gain and preventing the redistribution of body fat is a major health issue, and could help prevent the onset of various symptoms of metabolic syndrome. Above all, it is important to understand the mechanisms by which these different treatments affect adipose tissue. To this end, the investigators will first study the impact of GLP-1 analogues on adipose tissue. The main objective is to show that subjects treated with a GLP-1 agonist have a significant change in their oxytocin levels compared with subjects not treated with a GLP-1 agonist.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patient over 18 years of age.
- Patient able to read and understand the information/consent leaflet.
- Patient with BMI \> 35 with at least one comorbidity. Or BMI \> 40
- Indication for digestive surgery validated in a multidisciplinary consultation meeting and prior agreement accepted by the CPAM.
- Membership of a social security scheme
- Patient's signed informed consent
- For subjects in the GLP-1 analogue group: GLP-1 analogue taken for at least 3 months.
- For non-GLP-1 analogue group: never taken GLP-1 analogues.
Exclusion criteria
- Pregnant or breast-feeding women.
- Vulnerable patients (under guardianship)
- Patients deprived of liberty
Where it is running
1 location listed.
- CHU de Nice - Hôpital de l'Archet - Nice, Alpes-maritimes, France