Motor-cognitive Performance in People With Multiple Sclerosis
Recruiting · NCT06312046 · Interventional (participants receive a specific treatment) · Lead sponsor: Karolinska Institutet
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Having a neurological disease such as multiple sclerosis (MS) leads to difficulties in balance and gait with or without concurrent performance of cognitive tasks, hindering activity performance and influencing the possibilities for an independent lifestyle. The investigators have adapted a previously developed balance training program to a highly challenging program specifically directed to MS (HiBalance-MS). This program was recently tested and found feasible in a pilot study. The investigators will now perform a randomized controlled trial in people with MS, in order to determine the effects of the program. The hypothesis is that progressively challenging balance exercise programs that are specific to the balance control domains affected by MS will be effective to improve balance control, walking, motor-cognitive performance, activity performance and health related quality of life.
Who can take part
Inclusion criteria
- an MS diagnosis according to McDonald criteria;
- an overall MS-disability score from 2.0 to 5.5 according to the Expanded Disability Status Scale;
- ability to walk 100 m without aid;
- a maximum score of 24 in the Mini-BESTest (i.e., \< 25 points)
- 18 to 65 years of age
Exclusion criteria
- cognitive impairment as indicated by a score \<21 in the Montreal Cognitive Assessment;
- presence of other conditions that would substantially influence balance;
- an MS relapse or change of disease-modifying treatment within the past 8 weeks
Where it is running
1 location listed.
- Karolinska Institutet - Stockholm, Stockholm County, Sweden