Early Onset Colorectal Cancer Detection
Recruiting · NCT06342401 · Observational (researchers observe without assigning treatment) · Lead sponsor: City of Hope Medical Center
View the official record on ClinicalTrials.gov →Interventions studied
ENCODE
What this trial is about
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)
Who can take part
Age range
18 Years to 50 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Stage I, II, III, IV colorectal cancer (TNM classification, 8th edition) diagnosed before the age of 50 (EOCRC cases)
- Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment
- Colonoscopy-proven cancer-free status at the time of study inclusion (Non-disease controls)
Exclusion criteria
- Hereditary colorectal cancer syndromes (identified through genetic testing)
- Inflammatory bowel diseases
- Lack of written informed consent
Where it is running
13 locations listed across 1 US state.
- City of Hope Medical Center - Duarte, California, United States
- Barcelona University - Barcelona, Spain
- Colorectal Surgery, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona UAB - Barcelona, Spain
- Surgery Department, Hospital del Mar, Barcelona, Spain - Barcelona, Spain
- Kawasaki University - Kawasaki, Japan
- Salamanca Biomedical Research Institute - Madrid, Spain
- Mie University - Mie, Japan
- IRCCS San Raffaele - Milan, Italy
- University of Salamanca-SACYL-CSIC, Salamanca, Spain - Salamanca, Spain
- University of La Laguna - San Cristóbal de La Laguna, Spain
- National Cancer Center Hospital - Tokyo, Japan
- Tokyo Medical and Dental University - Tokyo, Japan
- Yamagata University - Yamagata, Japan