Early Detection of Advanced Adenomas and Colorectal Cancer
Recruiting · NCT06342440 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
DENEB
What this trial is about
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
- Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
- Received standard pathological and endoscopic diagnosis and assessment for cohort assignment.
Exclusion criteria
- Hereditary colorectal cancer syndromes (identified through genetic testing).
- Inflammatory bowel diseases.
- Lack of written informed consent.
Where it is running
6 locations listed across 1 US state.
- City of Hope Medical Center - Monrovia, California, United States
- University of California San Diego - San Diego, California, United States
- Barcelona University - Barcelona, Spain
- The First Affiliated Hospital of Dalian Medical University - Dalian, China
- Mie University - Mie, Japan
- IRCCS San Raffaele - Milan, Italy