Pilot Study of the Human Metagenome in Metabolic Diseases
Recruiting · NCT06363253 · Observational (researchers observe without assigning treatment) · Lead sponsor: Sengkang General Hospital
View the official record on ClinicalTrials.gov →Interventions studied
No specific intervention
What this trial is about
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia. Recruited participants will have their fecal, salivary, urine, serum, and in certain instances, mucosal samples taken, for metagenomic sequencing and metabolite testing. We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states, with potential future therapeutic applications in personalised medicine.
Who can take part
Age range
21 Years to 99 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- bese cohort):
- Obese (BMI\>27.5kg/m2)
- Inclusion Criteria (sarcopenic cohort):
- Sarcopenic patients, defined as 1) low handgrip strength (\<26 for males; \<18kg for females), AND/OR low gait speed (\<0.8m/s) AND low muscle mass (\<7.0kg/m2 for males; \<5.7kg/m2 for females)
- Inclusion Criteria (control cohort):
- \- Healthy subjects without sarcopenia, and not obese (BMI\<27.5kg/m2)
Exclusion criteria
- No informed consent
- Presence of intestinal stoma, hence inability to collect fecal samples
Where it is running
1 location listed.
- Sengkang General Hospital - Singapore, Singapore