The Acute T-Rex (Timing of Resistance Exercise) Study

Recruiting · NCT06366399 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Utah

View the official record on ClinicalTrials.gov →

Type 2 diabetes Obesity

Interventions studied

Resistance Exercise Timing

What this trial is about

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Who can take part

Age range

50 Years to 74 Years

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

Men and women, all ethnicities, aged 50-74 years
BMI ≥25 kg/m² and \<45 kg/m²
Weight stable (less than 5% change in the past 6 months)
Generally healthy individuals
Not meeting recommended activity guidelines for aerobic or resistance exercise

Exclusion criteria

Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
Cancer treatment in the past 5 years
Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
Current use of weight loss medication or other medications likely to impact energy balance
Bariatric surgery or extensive bowel resection in the past 2 years
Current or recent history (past 2 years) of eating disorder
Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
Non-English speaking
HbA1c \>6.5%

Where it is running

2 locations listed across 1 US state.

University of Utah HPER E Buildling - Salt Lake City, Utah, United States
University of Utah HPER E Buildling - Salt Lake City, Utah, United States

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →