REtinal Markers In Neuroinflammatory Diseases ("REMIND")
Recruiting · NCT06369766 · Observational (researchers observe without assigning treatment) · Lead sponsor: University Hospital, Basel, Switzerland
View the official record on ClinicalTrials.gov →Interventions studied
Dynamic retinal vessel analyzerLaser speckle flowgraphy systemOptical coherence tomography (OCT)QuestionnaireStatic retinal vessel analyzer
What this trial is about
The goal of this observational study, including patients with Multiple Sclerosis, patients with other neuroinflammatory diseases and healthy controls, is to determine the predictive value of retinal markers in predicting disease progression. Participants complete a questionnaire and undergo various non-invasive retinal routine clinical examinations.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- All groups:
- Age \>18 years old
- Patients with Multiple Sclerosis:
- Diagnosis of Multiple Sclerosis, according to the last revisions of the McDonald Criteria (2017)
- Patients with other neuroinflammatory diseases:
- Diagnosis of Neuromyelitis optica spectrum disorder or Myelin oligodendrocyte glycoprotein antibody disease or other neuroinflammatory disorders other than Multiple Sclerosis
Exclusion criteria
- All groups:
- Inability to undergo Optical Coherence Tomography (OCT) and/or retinal vessel imaging (e.g. severe nystagmus that prevents eye fixation on both eyes)
- Presence of any ocular pathology that may interfere with the validity of the OCT/retinal vessel analysis (cataracts, glaucoma, history of refractive defects \>6 D etc.).
- Pregnancy and Lactation
- Healthy Controls
- History of other neurological conditions: participants with a history of other significant neurological conditions that might interfere with the assessment or interpretation of the signs and symptoms will be excluded (e.g. confirmed Stroke, Acute disseminated encephalomyelitis, Chronic inflammatory Demyelinating Disease, Polyneuropathy, etc.)
Where it is running
1 location listed.
- University Hospital Basel, Department of Neurology - Basel, Switzerland