BAI-BACE for Advanced Lung Squamous Cell Carcinoma
Recruiting · NCT06377735 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
BAI-BACE
What this trial is about
Bronchial arterial infusion plus bronchial arterial chemoembolization (BAI-BACE) has been reported as non-first-line therapy to treat lung cancer in many hospitals in China. BAI, which uses chemotherapeutic drugs directly injected into the tumor and achieved a high concentration in a short time to kill the tumor. Then BACE could seal off the tumor vessels. In this study, we aim to describe the efficacy and safety of BAI-BACE as non-first-line for advanced lung squamous cell carcinoma.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Squamous cell carcinoma diagnosed by pathology, and central location by imaging;
- Age 18-80;
- Patients failed to the standard first-line or second-line treatment;
- Tumors limited in the chest;
- Tumors were fed by bronchial artery through CTA reconstruction;
- Patents received PD-1 inhibitor or not were also included;
- Eastern Cooperative Oncology Group performance status (ECOG PS) of 0-2;
- Images within 2 weeks before inclusion;
- Life expectancy more than 3 months;
- Agreed to participated in this clinical trial;
- Hemameba ≥3.0 x109/L, neutrophil ≥1.5x109/L, hemoglobin≥10.0 g/L, platelet≥100x 109/L, ALT; AST; bilirubin ≤1.5-fold normal, GFR≥60ml/min.
Exclusion criteria
- Contraindication of BAI or BACE;
- Under 18 years or over 75 years;
- extra-chest metastases;
- Receiving other antitumor treatment;
- Severe infection or pregnancy;
- Severe Pulmonary fibrosis and pulmonary artery;
- liver, kidney or poor physical conditions;
- Severe pleural effusion or pericardial effusion;
- Life expectancy less than 3 months.
Where it is running
1 location listed.
- Chinese PLA General hospital - Beijing, Beijing Municipality, China