The PRO-FUTURE Project
Recruiting · NCT06382233 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Campania Luigi Vanvitelli
View the official record on ClinicalTrials.gov →Interventions studied
Identification of Diagnostic Biomarkers
What this trial is about
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are: * Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? * Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?
Who can take part
Age range
1 Day to 5 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- unilateral UPJO
- 0-5years of age
Exclusion criteria
- bilateral UPJO
- previous surgical intervention on the urinary tract
- bladder or lower urinary tract symptoms or malformations
- nephro- or urolithiasis, vesicoureteral reflux
- urinary tract infections.
Where it is running
5 locations listed.
- Department of Clinical Sciences and Community Health, University of Milano - Milan, Italy
- Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico - Milan, Italy
- Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia - Modena, Italy
- AORN Santobono-Pausilipon - Naples, Italy
- Univeristà degli Studi della Campania Luigi Vanvitelli - Naples, Campania, Italy