The Efficacy and Safety of Precision REpetitive Transcranial Magnetic Stimulation in Alleviating Motor Symptom in Parkinson's Disease
Recruiting · NCT06383247 · Interventional (participants receive a specific treatment) · Lead sponsor: Anhui Medical University
View the official record on ClinicalTrials.gov →Interventions studied
transcranial magnetic stimulation
What this trial is about
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and widely used neuromodulation technology. Small sample studies have shown that rTMS treatment can significantly improve the symptoms of Parkinson's disease(PD) and delay the progression of the disease. In order to further explore the effectiveness of rTMS in the treatment of PD and lay the foundation for its clinical promotion, our research team plans to conduct a randomized double-blind controlled study of rTMS in the treatment of PD in multiple centers across the country.
Who can take part
Age range
40 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥ 40 years old;
- Meet the diagnostic criteria for idiopathic Parkinson's disease (MDS Diagnostic Criteria for Parkinson's Disease (2015 Edition))\[1\];
- Have no history of drug adjustment within 4 weeks before treatment and the entire study period;
- The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4;
- MMSE ≥22，able to cooperate with the completion of behavioral tests and transcranial magnetic stimulation therapy.
Exclusion criteria
- Previously head MRI/CT was focal brain injury or severe leukoencephalopathy (Fazekas grade 3 and above);
- Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonism combined with parkinsonism, drug parkinsonism, etc.);
- Severe craniocerebral trauma, received craniocerebral surgery or deep brain stimulation treatment;
- There are ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.
- The person has a history of epilepsy, unexplained loss of consciousness, or are taking anticonvulsant drugs to treat epileptic seizures;
- Diagnosed with a neuropsychiatric disorder other than PD
- Have a history of drug abuse or drug use;
- Participants in any clinical trial within the previous 6 month;
- Pregnant/lactating women or subjects (including men) who have a birth plan within 6 months;
- Other conditions deemed unsuitable for inclusion by the investigator.
Where it is running
1 location listed.
- Cognitive Neuropsychology Lab Anhui Medical University - Hefei, Anhui, China