Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis
Recruiting · NCT06390696 · Interventional (participants receive a specific treatment) · Lead sponsor: Natural Resources Institute Finland
View the official record on ClinicalTrials.gov →Interventions studied
Microbial interventionPlacebo
What this trial is about
The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood. Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.
Who can take part
Age range
2 Years to 5 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Eczema Area and Severity Index ≥ 2
Exclusion criteria
- Eczema Area and Severity Index \< 2
- Immune deficiencies, i.e., antibody deficiency
- Immunosuppressive systematic medications
- A disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, Crohn's disease, diabetes)
- Cancer diagnosis
- Topical medication for the treatment of atopic dermatitis during the trial
- Disability affecting the immune response (e.g. Down's syndrome)
- Non-participation in the national vaccine program
- Participation in another intervention or follow-up study
Where it is running
2 locations listed.
- Tampere University - Tampere, Finland
- Natural Resources Institute Finland - Helsinki, Uusimaa, Finland