Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension
Recruiting · NCT06409624 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
No intervention is planned as part of the study
What this trial is about
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Inpatients aged ≥18 years
- Undergoing right heart catheterization (RHC)
Exclusion criteria
- multifactorial or indeterminate PH, for which no single underlying mechanism could be reliably classified
- active tumor disease requiring targeted therapy
- inflammatory or autoimmune disease with renal involvement requiring systemic immunosuppressive treatment
- unexplained kidney function decline, defined as serum creatinine increase ≥0.5 mg/dL from baseline within the prior 7 days before RHC
- Chronic kidney disease with eGFR \<20 ml/min/1.73 m2
- non-kidney failure requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload
- if they had received non-steroidal anti-inflammatory drugs or intravenous contrast within 72 hours before RHC
- prediagnosed glomerulonephritis
- polycystic kidney disease
- postrenal obstruction
- single kidney (functional or anatomical)
- solid organ transplantation
- anticipated life expectancy of \<12 months
- likelihood of receiving advanced therapy (mechanical circulatory assist device/lung or cardiac transplant)
- pregnancy or possibility of pregnancy in the next 12 months
- inability to cooperate with respiratory maneuvers during renal Doppler
- refusal to participate
- not available for follow-up visits
Where it is running
4 locations listed.
- Kerckhoff Klinik Heart and Thorax Center - Bad Nauheim, Hesse, Germany
- Kerckhoff Klinik Heart and Thorax Center - Bad Nauheim, Hesse, Germany
- University Hospital Giessen and Marburg, Campus Giessen, Department of Internal Medicine II - Giessen, Hesse, Germany
- University Hospital Giessen and Marburg, Campus Giessen, Department of Internal Medicine II - Giessen, Hesse, Germany