JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation
Recruiting · NCT06416410 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This Phase 3 study will evaluate the efficacy of JAB-21822+JAB-3312 versus tislelizumab (PD-1 Ab) combined with pemetrexed+carboplatin as the first line treatment in subjects with KRAS G12C mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- A signed written informed consent is required before performing any study-related operations
- Age greater than or equal to 18 years old
- Histologically or cytologically confirmed locally advanced/metastatic, unresectable non-squamous NSCLC with KRAS p. G12C mutation confirmed by the central lab
- No history of systemic anticancer therapy to the local advanced/metastatic disease
- Expected survival period greater than or equal to 3 months
- Having at least one target lesion according to RECIST 1.1
- Eastern Cooperative Oncology Group (ECOG) ≤ 1
Exclusion criteria
- Previous (≤2 years) or current solid tumors or hematologic tumors of other pathological types
- Carry other driver gene mutations with available target therapy, or carry other KRAS mutations
- Subjects with untreated central nervous system (CNS) metastases were excluded;
- Uncontrolled pleural effusion, pericardial effusion, and ascites
- Subjects with impaired heart function or clinically significant heart disease
Where it is running
37 locations listed.
- Anhui Province cancer hospital - Hefei, Anhui, China
- Pecking Union Medical College Hospital - Beijing, Beijing Municipality, China
- Cancer Hospital Chinese Academy Of Medical Sciences - Beijing, Beijing Municipality, China
- Beijing Tiantan Hospital, Captal Medical University - Beijing, Beijing Municipality, China
- Beijing Cancer Hospital - Beijing, Beijing Municipality, China
- Peking University Third Hospital - Beijing, Beijing Municipality, China
- Beijing Chest Hospital ,Capital Medical University - Beijing, Beijing Municipality, China
- Fujian cancer Hospital - Fuzhou, Fujian, China
- The first Affiliated Hospital, Sun Yat-sen University - Guangzhou, Guangdong, China
- Cancer Hospital Chinese Academy Of medical Sciences Shenzhen Center - Shenzhen, Guangdong, China
- Guangxi Medical University Cancer hospital & Guangxi Cancer Institute - Nanning, Guangxi, China
- Cangzhou hospital of integrated TCM-WM Hebei - Cangzhou, Hebei, China
- Harbin Medical University Cancer Hospital-Mammary gland of internal - Haerbin, Heilongjiang, China
- Henan Cancer Hospital - Zhengzhou, Henan, China
- The First Affiliated Hosipital Of Zhengzhou University - Zhengzhou, Henan, China
- Union Hospital Tongji Medical College Huazhong University of Science and Technology - Wuhan, Hubei, China
- Tongji Hospital Tongji Medical College of Hust - Wuhan, Hubei, China
- Hubei cancer hospital - Wuhan, Hubei, China
- Hunan Cancer Hospital - Changsha, Hunan, China
- Jiangsu province hospital - Nanjing, Jiangsu, China
- Wuxi People's Hospital - Wuxi, Jiangsu, China
- Jilin cancer hospital - Jilin City, Jilin, China
- The First Hospital Of China Medical University - Shenyang, Liaoning, China
- Liaoning Cancer Hospital & Institute - Shenyang, Liaoning, China
- Shandong Cancer Hospital - Jinan, Shandong, China
- LinYi Cancer Hospital - Linyi, Shandong, China
- The affiliated hospital of Qingdao university - Qingdao, Shandong, China
- Fudan University Shanghai Cancer Center - Shanghai, Shanghai Municipality, China
- Shanghai Pulmonary Hospital - Shanghai, Shanghai Municipality, China
- Shanxi province cancer hospital - Taiyuan, Shanxi, China
- The First Affiliated Hospital of Xi'An Jiaotong University - Xi’an, Shanxi, China
- Sichuan province cancer hospital - Chengdu, Sichuan, China
- West China Hospital Sichuan University - Chengdu, Sichuan, China
- Tianjin Medical University Cancer Institute Hospital - Tianjin, Tianjin Municipality, China
- The First affiliated hospital Zhejiang university school of medicine - Hangzhou, Zhejiang, China
- The Second Affiliated Hospital Zhejiang School of Medicine - Hangzhou, Zhejiang, China
- Taizhou Hospital Zhejiang Province - Taizhou, Zhejiang, China