Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial
Recruiting · NCT06442033 · Interventional (participants receive a specific treatment) · Lead sponsor: Jay Alberts
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.
Who can take part
Inclusion criteria
- Adult with a diagnosis of PD by a physician or physician extender
- Hoehn and Yahr stage I-III
- Demonstrate the ability to safely mount and dismount a stationary cycle
- Reliable transportation to the community exercise facility
- Smartphone device for activity data monitoring
- On a stable dose of anti-parkinsonian medication
Exclusion criteria
- Participation in disease modifying PD-related clinical trial or study
- Diagnosis of dementia or any neurocognitive impairment that compromises one's ability to provide informed consent.
- Implanted deep brain stimulation electrodes or focused ultrasound for PD management
- Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen a. If the ACSM screen recommends medical clearance, the participant must obtain medical clearance by their health care provider prior to participation.
- b. Those who choose not to obtain physician clearance will not be eligible for participation.
- e) A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in a cycling intervention f) Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) g) Current cardiac arrhythmia
Where it is running
1 location listed across 1 US state.
- The Cleveland Clinic - Cleveland, Ohio, United States