Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
Recruiting · NCT06444646 · Observational (researchers observe without assigning treatment) · Lead sponsor: Hasselt University
View the official record on ClinicalTrials.gov →Interventions studied
Adipose tissue biopsyBlood samplingPatient phenotypingQuestionnaire
What this trial is about
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m\^2 and are scheduled for their first bariatric surgery.
- Final male/female ratio of this study is 1:1
- Minimal knowledge of Dutch to read and understand the informed consent.
- Individuals with obesity -
Exclusion criteria
- Smoking and/or drug abuse
- Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)
- Lung and/or kidney diseases
- Brain and/or nerve diseases
- Malignant diseases (e.g. cancer)
- Individuals without obesity (lean) - inclusion criteria
- Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg/m\^2 and are scheduled for abdominal surgery
- Female only
- Minimal knowledge of Dutch to read and understand the informed consent.
- Individuals without obesity (lean) - exclusion criteria
- Smoking and/or drug abuse
- Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)
- Lung and/or kidney diseases
- Brain and/or nerve diseases
- Endocrine diseases like type 2 diabetes
- Malignant diseases (e.g. cancer)
Where it is running
1 location listed.
- Ziekenhuis Oost-Limburg - Genk, Limburg, Belgium