Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer
Recruiting · NCT06449989 · Observational (researchers observe without assigning treatment) · Lead sponsor: Blokhin's Russian Cancer Research Center
View the official record on ClinicalTrials.gov →Interventions studied
Tumor samples will be tested for mutation status of KRAS, NRAS, BRAF, HER2 and MSI
What this trial is about
GENCONCOR-1 study is translational research aimed to investigate the concordance of the molecular genetic profile of the primary tumor and brain metastases (BM) of colorectal cancer (CRC). The study was conducted by post hoc analysis of pairs of samples of histological material with determination of the mutational status of genes KRAS, NRAS, BRAF, HER2 and MSI.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Men and women over 18 years of age.
- Histologically confirmed cancer of the colon or rectum.
- Histologically confirmed metastatic lesion of the brain.
- Neurosurgical resection for brain metastases of colorectal cancer.
- Presence of paired tumor samples (both primary tumor and intracranial material).
Exclusion criteria
- Missing one sample from a pair of tumor samples.
- Low quality or lack of tumor material for molecular genetic research.
Where it is running
1 location listed.
- Blokhin's Russian Cancer Research Center - Moscow, Moscow, Russia