Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography
Recruiting · NCT06465498 · Interventional (participants receive a specific treatment) · Lead sponsor: Antonio Leidi
View the official record on ClinicalTrials.gov →Interventions studied
LUS decongestive strategyPE decongestive strategy
What this trial is about
The goal of this clinical trial is to investigate whether a lung ultrasonography (LUS)-guided decongestion strategy in adults hospitalized for acute heart failure (AHF) can improve patient-centered outcomes. The main questions it aims to answer are: * Does this strategy shorten the length of stay and reduce early hospital readmissions? * Does this strategy improve patients' symptoms and quality of life ? Researchers will compare LUS to physical examination (PE).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- ≥ 18 years old
- Planned or actual admission to intermediate care units, general internal medical or cardiology wards
- Diagnosis of congestive AHF on admission chart (primary or secondary diagnosis)
- Raised value of N terminal-pro-brain natriuretic peptide (≥1000 ng/l).
- Key
Exclusion criteria
- Known isolated right heart failure
- Systolic blood pressure \<90 mmHg, mean arterial pressure \<65 mmHg at the moment of inclusion
- The following conditions mimicking lung cardiogenic oedema on LUS if known at inclusion and documented: Interstitial lung disease, lung cancer or metastasis, acute respiratory distress syndrome, pulmonary contusion
- Known virologically confirmed SARS-CoV-2 pneumonia in the preceding 3 months
- Unwillingness to give consent
- Subjects who are pregnant or breastfeeding
- Hospitalisation for palliative care and probable end-life within 30 days
Where it is running
5 locations listed.
- Fribourg University Hospital - Fribourg, Switzerland
- Ospedale Civico, Ente Ospedaliero Cantonale - Lugano, Switzerland
- Trois-Chêne Hospital, Geneva Univesity Hospitals - Geneva, Canton of Geneva, Switzerland
- Geneva University Hospitals - Geneva, Canton of Geneva, Switzerland
- Inselspital, Universitätspital - Bern, Switzerland, Switzerland