Sensitivity of Organoids to Predict Treatment Outcome in Breast Cancer Metastases
Recruiting · NCT06468124 · Observational (researchers observe without assigning treatment) · Lead sponsor: King's College London
View the official record on ClinicalTrials.gov →What this trial is about
The aim of the study is to generate patient-derived organoids (PDOs) from brain resection or biopsied extra-cranial metastases. The preliminary data collected will be used to assess the ability of PDOs to predict patients' treatment response and their radio-sensitivity and chemo-sensitivity can be correlated with their survival outcome.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Breast cancer patients with brain metastases who are suitable for surgical resection or Breast cancer patients with extra-cranial metastases undergoing surgical resection or biopsy
- Age \> 18 years old
Exclusion criteria
- Patients unable to give informed consent e.g., mental disability or vulnerable adults
Where it is running
2 locations listed.
- Guy's and St. Thomas NHS Foundation Trust - London, United Kingdom
- King's College Hospital NHS Foundation Trust - London, United Kingdom