Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery
Recruiting · NCT06475547 · Observational (researchers observe without assigning treatment) · Lead sponsor: Odense University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, marked by an irregular and rapid heart rate, and associated with increased morbidity, longer hospital stays, and higher costs. Its complex pathophysiology involves atrial remodeling, inflammation, and autonomic dysregulation. Surgical trauma and cardiopulmonary bypass trigger an inflammatory response, releasing cytokines. Epicardial fat around the heart secretes pro-inflammatory cytokines, and its increased thickness is linked to higher inflammation and atrial fibrillation. This study uses RNA sequencing (RNA-seq) to profile gene expression in epicardial fat, identifying key genes involved in inflammation and metabolism. By comparing patients with and without POAF, RNA-seq reveals differentially expressed genes associated with postoperative atrial fibrillation.
Who can take part
Inclusion criteria
- Age \> 18
- Informed consent
Exclusion criteria
- Incompetent individuals
- General poor health condition at the time of inclusion
- Reoperation
Where it is running
1 location listed.
- Odense University Hospital, Cardiac Surgery Department - Odense, Denmark