RACE-2L: Real-World Assessment of Clinical Practice and Outcomes in Non-squamous NSCLC After Failure of Platinum-based Chemotherapy in Brazil
Recruiting · NCT06491862 · Observational (researchers observe without assigning treatment) · Lead sponsor: AstraZeneca
View the official record on ClinicalTrials.gov →What this trial is about
The study will be implemented as a retrospective, noninterventional medical record review of patients from routine practice settings who have been diagnosed with a/m non-squamous NSCLC with or without AGA and received at least 1 line of systemic treatment after failing PTC between January 2017 and December 2024.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Confirmed diagnosis of patients with non-squamous NSCLC stage IIIB/IIIC not eligible for curative-intent therapies or stage IV/M1 (a/m NSCLC) with or without actionable genomic mutations (i.e., EGFR, ALK, ROS1, NTRK, BRAF, MET exon 14 skipping, RET, HER-2)
- Aged at least 18 years at first diagnosis of a/m NSCLC
- For the AGA subgroup, having received platinum-based chemotherapy, having received at least one target approved therapy.
- For the non\_AGA subgroup,should have received either sequential or concurrent use of ICI and PTC)
- Patient must have received at least line of therapy of an active agent after failing PTC.
Exclusion criteria
- Patients with evidence of other primary malignancies (apart from basal cell carcinoma and melanoma) within 1 year prior to the index date will be excluded from both the study cohorts.
- Patients who participated in an investigational clinical trial for the treatment of any cancer, including NSCLC, or any early access program from 2018 onward.
Where it is running
11 locations listed.
- Research Site - São Paulo, Brazil
- Research Site - São Paulo, Brazil
- Research Site - São Paulo, Brazil
- Research Site - São Paulo, Brazil
- Research Site - São Paulo, Brazil
- Research Site - São Paulo, Brazil
- Research Site - Belo Horizonte, Minas Gerais, Brazil
- Research Site - Belo Horizonte, Minas Gerais, Brazil
- Research Site - Natal, Rio Grande do Norte, Brazil
- Research Site - Porto Alegre, Rio Grande do Sul, Brazil
- Research Site - São José do Rio Preto, São Paulo, Brazil