The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease
Recruiting · NCT06501222 · Interventional (participants receive a specific treatment) · Lead sponsor: Yuanjun Yang
View the official record on ClinicalTrials.gov →Interventions studied
Remote ischemic conditioning
What this trial is about
The incidence of Chronic kidney disease (CKD) is showing an upward trend, but the therapeutic effect of treatment is limited. Remote ischemic conditioning (RIC) has the potential to safeguard remote organs via the repeated application of brief ischemic stimuli. the aim of our study is to investigate whether RIC can protect the renal function in patients with CKD.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- CKD Patients with eGFR ≥ 15ml/min/1.73m2
- Age ≥ 18 years old
- 24-hour urine protein excretion ≤ 3.5g
- Subjects who have signed the informed consent form
Exclusion criteria
- Patients with nephrotic syndrome
- Patients with acute kidney injury
- Patients who have undergone renal replacement treatment in the past
- Patients who may have medication changes during RIC or sham-RIC intervention
- Patients with a history of diabetes or glycated hemoglobin \> 8%
- Patients with familial hypercholesterolemia (\>5.5 mmol/L) accompanied by high low-density lipoprotein (\>2.5 mmol/L)
- Patients with contraindications to RIC, such as vascular injury, soft tissue injury, fracture, infection, or known peripheral vascular disease in both arms
- Patients with a history of hemostatic disorders, systemic bleeding, or thrombocytopenia
- Patients with cardiogenic embolism (atrial fibrillation) or other severe arrhythmias (severe bradycardia, third-degree atrioventricular block, or ventricular tachycardia), previous myocardial infarction, or severe heart failure (New York Heart Association Class III and IV)
- Uncontrolled hypertension (defined as systolic blood pressure ≥ 200 mmHg despite antihypertensive treatment)
- Patients with respiratory failure, malignant tumors, or other autoimmune diseases
- Women who are pregnant or breastfeeding at the time of enrollment or any time during the study
Where it is running
1 location listed.
- chinese PLA general hospital - Beijing, Beijing Municipality, China