Blood Flow Restriction for Optimizing Balance in Parkinson's Disease
Recruiting · NCT06508801 · Interventional (participants receive a specific treatment) · Lead sponsor: The University of Texas Health Science Center at San Antonio
View the official record on ClinicalTrials.gov →Interventions studied
Blood flow restriction trainingInstability Resistance Training
What this trial is about
This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.
Who can take part
Age range
40 Years to 85 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria,
- in Hoehn and Yahr stage 2-4,
- a score of ≥23 on the mini-Mental Scale Examination.
Exclusion criteria
- History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis;
- Ankle branchial index ≤ 0.9 or \> 1.3.
- History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy.
- History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment.
- Body mass index above 40; such individuals are more likely to have poorer muscle function and more pain.
- Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure
- Had surgery in the lower extremities within the past 6 months.
- Pre-menopausal and not on birth control
- Pregnant or planning to become pregnant within the course of the study
- Plan to have major surgery within 2 months.
Where it is running
1 location listed across 1 US state.
- University of Texas Health Science Center at San Antonio - San Antonio, Texas, United States