Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Recruiting · NCT06529744 · Observational (researchers observe without assigning treatment) · Lead sponsor: University Health Network, Toronto
View the official record on ClinicalTrials.gov →What this trial is about
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).
Who can take part
Age range
30 Years to 95 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Possible or probable diagnosis of MCI or early dementia
- Age 30-95
- Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
- Must, in the opinion of the site investigator, be able to complete most study procedures.
Exclusion criteria
- Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.
Where it is running
8 locations listed.
- Baycrest - North York, Ontario, Canada
- Baycrest - North York, Ontario, Canada
- Sunnybrook Health Sciences Centre - Toronto, Ontario, Canada
- Toronto Western Hospital, University Health Network - Toronto, Ontario, Canada
- Centre for Addiction and Mental Health - Toronto, Ontario, Canada
- Sunnybrook Health Sciences Centre - Toronto, Ontario, Canada
- Toronto Western Hospital, University Health Network - Toronto, Ontario, Canada
- Centre for Addiction and Mental Health - Toronto, Ontario, Canada