Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia
Recruiting · NCT06534658 · Observational (researchers observe without assigning treatment) · Lead sponsor: Ruijin Hospital
View the official record on ClinicalTrials.gov →What this trial is about
This project is a multicenter observational study that establishes a longitudinal cohort of patients with Alzheimer's disease and other dementias based on neuroimaging, molecular imaging, biological and digital markers to explore new solutions such as dementia disease mechanism, diagnosis, condition evaluation, and prognosis assessment.
Who can take part
Age range
50 Years to 85 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Patients aged ≥50 and ≤85 years old, male or female;
- Meet the diagnostic criteria for dementia or MCI;
- Neuropsychological score: MMSE 15-28 points, CDR ≤ 1 point; ④ Patients and their families are informed and sign the informed consent form
Exclusion criteria
- The presence of other neurological diseases that may cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.);
- The presence of other systemic diseases that may cause cognitive impairment (such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
- Suffering from a disease that makes it impossible to cooperate with cognitive examinations;
- The presence of contraindications to MRI;
- The presence of mental and neurological retardation;
- Refusing to draw blood;
- Refusing to sign the informed consent form.
Where it is running
8 locations listed.
- Chinese People's Liberation Army General Hospital - Beijing, Beijing Municipality, China
- First Affiliated Hospital of Zhejiang University School of Medicine - Hanzhong, Hangzhou, China
- Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine - Cangzhou, Hebei, China
- The Second Hospital of Hebei Medical University - Shijiazhuang, Hebei, China
- Qilu Hospital of Shandong University, Qingdao Branch - Qingdao, Shandong, China
- Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine - Shanghai, Shanghai Municipality, China
- Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine - Shanghai, Shanghai Municipality, China
- The First Affiliated Hospital of China Medical University - Shenyang, Shenyang, China