Dietary Intervention on Atopy
Recruiting · NCT06547372 · Interventional (participants receive a specific treatment) · Lead sponsor: National University of Singapore
View the official record on ClinicalTrials.gov →Interventions studied
Dietary Intervention on Atopy
What this trial is about
Diet is a key determinant of overall health, with growing evidence associating dietary patterns with allergic diseases. Among these, atopic dermatitis (AD) is of particular interest as it often represents the earliest manifestation of the atopic triad. Investigating dietary interventions in AD therefore provides a relevant model to better understand how diet may influence the onset and progression of allergic disease more broadly.
Who can take part
Age range
21 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Presence of current, mild-to-moderate atopic dermatitis/eczema at flexural areas
- 21 to 65 years of age (inclusive) at screening
- Must be English-literate and able to give informed consent in English
- Be residing in Singapore and will not be travelling outside of Singapore during the study period
- Reliable and willing to follow study procedures and be available for the duration of the study
- Non-smokers (tobacco and e-cigarette)
- Non-drinker (no regular or frequent consumption of alcohol)
- Overtly healthy with no pre-existing medical conditions (e.g., diabetes, hypertension, cancer, blood disorders, degenerative/liver/autoimmune/immune/renal diseases, or psychiatric conditions)
- No food allergies to test foods
- No needle phobia
- Be willing to follow the instruction provided by the investigators on the use of any moisturiser, cosmetics, and/or topical cream on the skin throughout the entire duration of the study.
Exclusion criteria
- Concurrent participation in other research studies
- Pregnancy or lactating individuals
- Known or ongoing psychiatric disorders within 3 years
- Known severe nutritional deficiency
- Vegetarian/vegans (as meat will be included in the diet)
- Individuals who made a significant dietary change in the past 12 months
- Having a pre-existing dietary restriction that would interfere with the adherence to a whole diet meal
- Regular use of strong medication (western and/or traditional), therapies, and alternative medications
- Regular nutritional supplements in the past 12 months Regular consumption of oral contraceptive pills and/or steroid hormones
- Antibiotic use in the past 2 months
- Any long-term hospitalisation or surgery during the 6 months before enrolment in study
- Significant change in weight (+/- 5.0%) during the past month
- History of bleeding diathesis or coagulopathy (or any bleeding disorders)
- Having donated blood of more than 500 mL within 4 weeks of study enrolment
Where it is running
1 location listed.
- National University of Singapore - Singapore, Singapore, Singapore