Multimodal Prognostic Assessment of Acute Ischemic Stroke Patients With Atrial Fibrillation: a Prospective, Multicenter, Observational Study (IAT-CLOSURE)
Recruiting · NCT06548269 · Observational (researchers observe without assigning treatment) · Lead sponsor: Jinan Central Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Cardiologic work-up
What this trial is about
The main purpose of this study is to investigate the safety and outcomes of different treatment strategies, including best medical therapy (OAC \[oral anticoagulation\], antiplatelet \[APT\]) and left atrial appendage closure \[LAAC\] in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) based on multimodal assessment from combined brain and cardiologic work-up, and to optimize secondary prevention.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Age \> 18 years old；
- Acute ischemic stroke with onset ≤ 14 days；
- Previously or during this hospitalization diagnosed with non-valvular atrial fibrillation;
- Informed consent obtained from the patient or his/her legal representative；
Exclusion criteria
- Pacemaker, implantable cardioverter defibrillator or implantable cardiac monitor;
- Left atrial appendage has been removed or post occlusion device implantation;
- Transient AF secondary to other reversible disorders；
- Life expectancy less than 1 year;
- Patients that cannot complete subsequent follow-up (e.g. no fixed residence, overseas patients, etc.);
- Females who are pregnant or in lactation;
- Participating in other clinical trials that could confound the evaluation of the study;
- Other circumstances that the investigator considers inappropriate for participation or may pose a significant risk to patients.
Where it is running
1 location listed.
- Jinan Central Hospital - Jinan, Shandong, China