Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
Recruiting · NCT06560840 · Interventional (participants receive a specific treatment) · Lead sponsor: Fudan University
View the official record on ClinicalTrials.gov →Interventions studied
dietary intervention
What this trial is about
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in preventing ASCVD among older people living with HIV (PLWH).
Who can take part
Age range
40 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- HIV-infected patients diagnosed according to the diagnostic criteria of China AIDS diagnosis and treatment guidelines;
- Aged 40 years and above;
- at risk of CVD: having any two of those risk factors: dyslipidemia, DM or elevated blood glucose, smoking, hypertention or elevated blood pressure, metabolic syndrome,overweight/obesity; or PCE score\>5%,
- Those with a predicted survival time of \>1 year;
- No plans to leave the depth in the next 3 months;
- Voluntary participation in this study and signing the informed consent
Exclusion criteria
- Those with a previous history of CVD;
- Those with HIV-related neurocognitive impairment, Alzheimer's disease or dementia, and a variety of serious opportunistic infections;
- Currently suffering from malignant tumors, gastrointestinal diseases; People with an aversion to eating;
- Allergic to nuts and fish;
- People who take medicinal calcium \>1000 mg per day or omega-3 supplements;
- Plan to become pregnant within 6 months;
- Are participating in other HIV-related or dietary intervention-related scientific research programs.
Where it is running
1 location listed.
- The Third People's Hospital of Shenzhen - Shenzhen, China