Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease
Recruiting · NCT06565143 · Interventional (participants receive a specific treatment) · Lead sponsor: Anhui Medical University
View the official record on ClinicalTrials.gov →Interventions studied
Sham transcranial alternating current stimulationTranscranial alternating current stimulation
What this trial is about
To investigate the clinical effect neural mechanism of transcranial alternating current stimulation in early Alzheimer's disease
Who can take part
Age range
50 Years to 85 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Subject diagnosed with early Alzheimer's disease or related diseases according to NIA-AA criteria.
- Subjects must have a MMSE score between 10 and 27,indicating mild cognitive impairment or dementia.
- CDR score ≤ 2.
- Subject under treatment by IAChE for at least 3 months.
- psychotropic treatments are tolerated if they were administered and unchanged for at least 3 months.
Exclusion criteria
- CDR \> 2
- Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
- History of head injury,stroke,or other neurologic disease.
- Organic brain defects on T1 or T2 images.
- History of seizures or unexplained loss of consciousness.
- Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator.
- Family history of medication refractory epilepsy.
- History of substance abuse within the last 6 months.
Where it is running
1 location listed.
- Anhui Medical University - Hefei, Anhui, China