rTMS as an Intervention for Levodopa-induced Dyskinesia
Recruiting · NCT06570824 · Interventional (participants receive a specific treatment) · Lead sponsor: Danish Research Centre for Magnetic Resonance
View the official record on ClinicalTrials.gov →Interventions studied
active TMSsham TMS
What this trial is about
The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD). Specifically, the study aims to determine whether patterned stimulation of the pre-supplementary motor area (pre-SMA) can delay the onset of LID after levodopa intake and reduce LID severity in PD patients. This study will provide critical insights into potential targets for rTMS treatment, optimal rTMS parameters, and the mechanisms underlying LID in Parkinson's disease.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Clinically established or probable PD
- Clinical Diagnostic Criteria for Parkinson's Disease
- Peak-of-dose levodopa-induced dyskinesia.
- Stable antiparkinsonian medicine for at least four weeks.
- Signed informed consent.
Exclusion criteria
- Psychiatric disorders.
- Usage of antipsychotic medication, Donepezil, and GABAergic medications (such as pregabalin and gabapentin).
- Regular usage of benzodiazepines and opioids (more than once per week).
- History of neurological disease other than Parkinson's disease.
- History of epilepsy/conditions associated with increased risk to seizure-induction through TMS.
- Close relatives suffering from epilepsy/conditions associated with increased risk to seizure-induction through TMS.
- Contraindications for MRI scan
- Female participants of childbearing age must not be pregnant and that they must use contraception during the trial.
- Refuse to be informed about new health related information and accidental health related findings that might appear through participation in the study.
Where it is running
1 location listed.
- DRCMR - Hvidovre, Denmark