White Matter Plasticity in Schizophrenia
Recruiting · NCT06641297 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Maryland, Baltimore
View the official record on ClinicalTrials.gov →Interventions studied
Music video game
What this trial is about
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
Who can take part
Age range
15 Years to 45 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
- age 15-45
- able to provide informed consent
Exclusion criteria
- contraindications to MRI (metal implants, claustrophobia)
- medical condition that limits use of hands (ie, arthritis)
- Active or recent (within 6 months) substance use disorder other than nicotine
Where it is running
2 locations listed across 1 US state.
- Maryland Psychiatric Research Center - Catonsville, Maryland, United States
- University of Maryland Baltimore - Maryland Psychiatric Research Center - Catonsville, Maryland, United States