PROspective Master-protocol for Evaluation of Systemic THErapeutics in Elderly With Thoracic Malignancies
Recruiting · NCT06646471 · Interventional (participants receive a specific treatment) · Lead sponsor: GFPC Investigation
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The objective of the study is to prospectively generate real-life data in patients aged ≥70 years treated in first line for a thoracic tumor (Non-Small-Cell Lung Carcinoma) according to best standard of care as defined by the European Society for Medical Oncology (ESMO). This cohort will aim to: * characterize participants in terms of geriatrics, biology and carcinology * describe the treatment modalities by stage, as well as the results in terms of efficacy, safety and impact on quality of life. At the same time, exploratory sub-cohorts will be identified including participants treated uniformly with the same molecule, and/or the same innovative strategy. Participants will be followed in accordance with investigator's usual clinical practice at the corresponding site. They will be asked to: * visit the clinic as per physician's request for checkups and tests for assessing general condition and clinical efficacy and tolerance of current treatment. * perform the necessary regular para-clinical examinations (lab testing, imaging, re-biopsy). * provide blood samples for bio-bank repository * perform assessments specific to older adults * answer three quality of life questionnaires
Who can take part
Inclusion criteria
- Patient ≥70 years
- Non-small-cell lung cancer for which the multidisciplinary consultation required systemic treatment regardless of Tumor-Node-Metastasis (TNM) stage
- Patient naïve to systemic anticancer treatment for bronchial neoplasia
- Patient covered by social security
- Patient eligible for systemic treatment
- Systemic treatment with marketing authorization in the indication, available in routine care early access or compassionate access.
- Patient able to understand the protocol
- Patient not opposed to the collection of data concerning him/her
- Signature of study consent form.
Exclusion criteria
- Patients under guardians or curators
- Patient not under the care of the investigating center and not monitored by the investigating center
- Patient already treated with systemic therapy for NSCLC
Where it is running
41 locations listed.
- CH du Pays d Aix - Aix-en-Provence, France
- Hôpital Henri Duffaut - Avignon, France
- Institut du Cancer d'Avignon - Avignon, France
- CH Bastia - Bastia, France
- Oncologie Thoracique Hôpital Morvan - Brest, France
- Pneumologie Centre François Baclesse - Caen, France
- CH Métropole-Savoie - Chambéry, France
- Centre Hospitalier du Cotentin - Cherbourg, France
- CHU Hôpital Montpied - Clermont-Ferrand, France
- Pneumologie Hospices Civils de Colmar - Colmar, France
- Pneumologie CHI Creteil - Créteil, France
- CH Elbeuf - Elbeuf, France
- Polyclinique de Blois - La Chaussée-Saint-Victor, France
- CHD Les Oudairies - La Roche-sur-Yon, France
- CH La Rochelle - La Rochelle, France
- Hôpital A. Mignot - Le Chesnay, France
- Hôpital Robert Boulin - Libourne, France
- CHU Dupuytren - Limoges, France
- Hôpital de la Vallée - Service Pneumologie - Longjumeau, France
- Centre Léon Bérard - Lyon, France
- Hôpital Européen de Marseille - Marseille, France
- Oncologie Thoracique Hôpital Nord - Marseille, France
- GHEF Site de Meaux - Meaux, France
- Centre d Oncologie de Gentilly - Nancy, France
- Pneumologie CHR - Orléans, France
- Pneumologie Hôpital Cochin - Paris, France
- Pneumologie Hôpital Tenon - Paris, France
- Cantre Catalan d Oncologie - Perpignan, France
- CH Annecy Genevois - Pringy, France
- Pneumologie CHI Quimper - Quimper, France
- CHU Hôpital Ponchailloux - Rennes, France
- Pneumologie Hôpital Charles Nicolle - Rouen, France
- Pneumologie CHU Felix Guyon - Saint-Denis, France
- Pneumologie CHU St Etienne - Saint-Etienne, France
- Clinique Mutualiste - Saint-Nazaire, France
- CHU de la Réunion - Saint-Pierre, France
- CLCC Paul Strauss - Strasbourg, France
- Hôpital d'Instruction des Armées Saint-Anne - Toulon, France
- CHITS Toulon Sainte Musse - Toulon, France
- Oncologie CHBA - Vannes, France
- Hôpital Nord OUest - Villefranche-sur-Saône, France