AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
Recruiting · NCT06650995 · Interventional (participants receive a specific treatment) · Lead sponsor: Technical University of Munich
View the official record on ClinicalTrials.gov →Interventions studied
Exercise training
What this trial is about
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.
Who can take part
Age range
18 Years to 99 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Diagnosed heart failure with preserved ejection fraction
- Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion)
Exclusion criteria
- Paroxysmal, long-persistent or permanent atrial fibrillation
- Clinically unstable coronary artery disease or acute coronary syndrome
- Physical and/or mental inability to perform exercise testing
- Prior ablation therapy
- Precapillary pulmonary hypertension at rest
- Intracardiac shunts
- Left ventricular ejection fraction \<50%
- High-degree valve insufficiency or stenosis (greater than grade 1 at rest)
Where it is running
1 location listed.
- Department of Medicine, Division of Prevention and Sports Medicine TU Munich - Munich, Germany