AGMT Metastatic Colorectal Cancer Registry (mCRC) Third Line and Beyond
Recruiting · NCT06678919 · Observational (researchers observe without assigning treatment) · Lead sponsor: Arbeitsgemeinschaft medikamentoese Tumortherapie
View the official record on ClinicalTrials.gov →What this trial is about
Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States and Europe. Although selected patients with oligometastatic CRC undergo systemic therapy and surgery/local ablative therapy in curative intent, the treatment approach for the majority of metastatic CRC (mCRC) patients remains palliative with a median overall survival (OS) ranging between 9-38 months depending on various prognostic and predictive factors. Particularly in advanced stages (in the third line of therapy and beyond), interesting and promising results have recently been achieved with various treatment approaches. The aim of this registry is to establish a disease-specific registry to evaluate the treatment landscape of patients with mCRC who have already received at least two lines of therapy.
Who can take part
Inclusion criteria
- patients ≥ 18 years with tissue-based diagnosis of mCRC
- ≥ 2 prior lines of palliative systemic therapy including 5-FU, irinotecan, oxaliplatin, anti-VEGF, anti-EGFR (in case of RAS/BRAF wildtype), anti-PD1- therapy (in case of MSI/MMRd) . (Exception: Patients who have received mFOLFOXIRI +/- anti-VEGF or anti- EGFR- 1L therapy or patients with ineligibility to receive 5-FU, oxaliplatin or irinotecan can be included after 1st line.)
Exclusion criteria
- Due to the non-interventional design of this registry, there are no specific exclusion criteria
Where it is running
7 locations listed.
- Ordensklinikum Linz, BHS - Interne I - Linz, Austria
- KUK Linz - Med Campus III.: Univ.-Klinik für Hämatologie und Internistische Onkologie - Linz, Austria
- LKH Feldkirch: Innere Medizin II/ Interne E (Hämatologie und Onkologie) - Rankweil, Austria
- Department of Internal Medicine III, Paracelsus Medical University Salzburg - Salzburg, Austria
- Klinikum Steyr: Innere Medizin II: Onkologie, Gastroenterologie, Angiologie - Steyr, Austria
- Klinikum Wels: Abteilung für Innere Medizin IV - Wels, Austria
- KH Zams: Innere Medizin Internistische Onkologie und Hämatologie - Zams, Austria