Efficacy of Nerve Block Versus Botox in Chronic Migraine Management
Recruiting · NCT06684249 · Interventional (participants receive a specific treatment) · Lead sponsor: Zagazig University
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this clinical trial is to determine whether nerve block injections (specifically, supratrochlear and greater occipital nerve injections) are as effective as Botulinum toxin A (Botox) injections in treating chronic migraine in adults. The main questions it aims to answer are: * Do nerve block injections reduce the number of monthly migraine days compared to baseline? * Are there any differences in the frequency of migraine-related symptoms between the nerve block and Botox treatment groups? * Which treatment leads to higher patient satisfaction and improved quality of life? Participants in this study will: * Receive either nerve block injections or Botox injections every 12 weeks. * Visit the clinic once every month for follow-ups and assessments. * Maintain a headache diary to record the frequency and severity of their migraines and any adverse effects experienced. * Researchers will compare the outcomes of the two groups to determine if one treatment is superior in terms of efficacy and patient satisfaction.
Who can take part
Inclusion criteria
- Adults aged 18 to 65 years.
- Diagnosis of chronic migraine, defined as having headaches on 15 or more days per month for more than three months, with at least 8 of those days meeting criteria for migraine.
- Ability to provide informed consent and comply with study requirements.
- No changes in prophylactic migraine medications in the last 3 months.
Exclusion criteria
- History of allergy or hypersensitivity to local anesthetics or Botulinum toxin.
- Previous nerve block or Botox treatment within the last 6 months.
- Significant comorbid psychiatric or neurological disorders that could interfere with study participation or evaluation.
- Pregnancy or breastfeeding.
- Contraindications to either treatment as per product labels.
Where it is running
1 location listed.
- Zagazig University, Faculty of Medicine - Zagazig, Sharqia Province, Egypt